Humira (adalimumab) for rheumatoid arthritis
April 9, 2004 by admin · Leave a Comment
In December of 2002, Abbott Laboratories received FDA approval for Humira®, its human monoclonal antibody for the treatment of adults with moderate to severe rheumatoid arthritis. At that time, Biohorizon placed Humira in its High Impact Technology category and recommended preliminary assessment activites. In an April 2004 company news release, Abbott announced that worldwide sales of Humira had reached $149 million for the first quarter ending March 31, 2004 and provided worldwide sales guidance of more than $1.2 billion for 2005.
Humira is a human monoclonal antibody that is thought to exert its effect by interfering with the function of an inflammatory cytokine known as tumor necrosis factor alpha (TNF-a). TNF-a is thought to play a critical role in mediating the immune response that causes the signs and symptoms of rheumatoid arthritis and other autoimmune diseases. Humira is given subcutaneously by injection every two weeks. Other currently existing treatments for rheumatoird arthritis include Enbrel®, and Remicade® (both TNF-a biological response modifiers) and Amgen’s Kineret® (an Interleukin-1 inhibitor), all of which are relatively new.
Rheumatoid arthritis is a chronic autoimmune disease that causes pain and swelling of the joints and may progress to the point of joint destruction. It has been estimated that the incidence of rheumatoid arthritis in the United States is 70/100, 000 per year, with 1 to 2 % of the population ultimately affected.
Biohorizon has currently assigned Humira to the High Impact Technology category. At approximately $1200 per patient per month, it produces a significant cost increase when compared to the traditional disease modifying anti-rheumatic drugs such as methotrexate. Based on Abbott’s own reported and predicted sales numbers, diffusion seems to be occurring at an impressive rate. Biohorizon reiterates the need for health services organizations to plan for the continued and increased presence of Humira in rheumatoid arthritis treatment regimens.
Technology Details
Target Disease / Indication
Rheumatoid Arthritis
Technology Classification
Drug
Body System
Musculoskeletal System
Program Area
Medicine/Rheumatology
Regulatory Status
Approved
BioHorizon Impact Score
67/100 – High
